1. China: There is currently a delicate balance between competition and cooperation between the US and China that needs to be maintained. The US must find ways to compete with China economically while developing avenues of cooperation to reduce the risk of conflict.
2. Russia: It is essential that the US maintains good relations with Russia, as they are both nuclear powers. Biden will need to address Russian interference in the US 2020 election, though it is difficult given that the current US-Russia relationship is very strained.
3. War in the Middle East: While the Biden Administration is attempting to wind down US involvement in the Middle East, it will be important to resolve remaining conflicts in Iraq, Syria, and Afghanistan in order to reduce regional tensions and protect US and ally interests in the area. Biden will also have to manage US relations with regional powers like Saudi Arabia and Iran. Finally, Biden must address the presence of terrorist groups like Al-Qaeda, ISIL, and other extremist groups.